2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140611
    Propargyl-peg3-sulfone-peg3-propargyl 2055024-44-5
    Propargyl-peg3-sulfone-peg3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-peg3-sulfone-peg3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-peg3-sulfone-peg3-propargyl
  • HY-141032
    N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 2107273-62-9
    N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3
  • HY-140616
    DNP-PEG6-Boc
    DNP-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DNP-PEG6-Boc
  • HY-140375
    Tos-PEG3-C2-methyl ester 1239588-09-0
    Tos-PEG3-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG3-C2-methyl ester
  • HY-140411
    Bis-aminooxy-PEG7 1383980-52-6
    Bis-aminooxy-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-aminooxy-PEG7
  • HY-141160
    TCO-PEG6-acid 2353409-97-7
    TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG6-acid
  • HY-130910
    Propargyl-PEG8-SH 1422540-92-8
    Propargyl-PEG8-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG8-SH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG8-SH
  • HY-115414
    Bis-propargyl-PEG8 1092554-87-4
    Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG8
  • HY-168039
    Boc-NH-Piperidine-C5-OH 1229442-84-5
    Boc-NH-Piperidine-C5-OH is a PROTAC linker. Boc-NH-Piperidine-C5-OH can be used in the synthesis of PROTAC PIN1 degrader-1 (HY-168037).
    Boc-NH-Piperidine-C5-OH
  • HY-132089
    N-Boc-PEG3-t-butyl ester
    N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-PEG3-t-butyl ester
  • HY-133403A
    Biotin-C1-PEG3-C3-amine TFA 1334172-59-6
    Biotin-C1-PEG3-C3-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-C1-PEG3-C3-amine TFA
  • HY-132114
    Biotin-PEG3-pyridinrthiol
    Biotin-PEG3-pyridinrthiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG3-pyridinrthiol
  • HY-140612
    Propargyl-PEG4-Sulfone-PEG4-Boc 2055024-43-4
    Propargyl-PEG4-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Sulfone-PEG4-Boc
  • HY-141096
    Acid-PEG9-NHS ester 1895916-27-4
    Acid-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG9-NHS ester
  • HY-138487
    Benzyl-PEG5-acid 2514948-41-3
    Benzyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG5-acid
  • HY-143842
    Mal-amido-PEG3-alcohol
    Mal-amido-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG3-alcohol
  • HY-W096089
    Benzyl-PEG3-acid 127457-63-0
    Benzyl-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG3-acid
  • HY-130768
    N-(Azido-PEG3)-N-Fluorescein-PEG3-acid 2100306-50-9
    N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-Fluorescein-PEG3-acid
  • HY-138472
    Azido-PEG4-THP 145927-74-8
    Azido-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-THP
  • HY-143819
    Propargyl-PEG-amine 956348-61-1
    Propargyl-PEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Propargyl-PEG-amine
PROTAC Linkers Isoform Comparison

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